Asperfuran, a novel antifungal metabolite from Aspergillus oryzae.
نویسندگان
چکیده
Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 micrograms/ml.
منابع مشابه
Novel antifungal diketopiperazine from marine fungus.
Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.
متن کاملComparative Chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357)
Aspergillus oryzae and A. flavus are important species in industrial biotechnology and food safety and have been some of the first aspergilli to be fully genome sequenced. Bioinformatic analysis has revealed 99.5% gene homology between the two species pointing towards a large coherence in the secondary metabolite production. In this study we report on the first comparison of secondary metabolit...
متن کاملAchyranthes Aspera Leaf Extracts Inhibited Fungal Growth
The aim of the study was investigate antifungal activity of the various leaves extracs of Achyranthes aspera Linn.The aqueous,ethanol and methanol leaves extracts of Achyranthes aspera Linn. (Family:Amaranthaceae) were evaluated for antifungal activity against clinically important fungal spp viz. Candida albicans (MTCC 227), C.tropicalis (MTCC 750), C.krusei (ATCC 6258), C.kefyr (ATCC 4235), C....
متن کاملCulture condition-dependent metabolite profiling of Aspergillus fumigatus with antifungal activity.
Three sections of Aspergillus (five species, 21 strains) were classified according to culture medium-dependent and time-dependent secondary metabolite profile-based chemotaxonomy. Secondary metabolites were analysed by liquid chromatography-electrospray ionisation tandem mass spectrometry (LC-ESI-MS-MS) and multivariate statistical methods. From the Aspergillus sections that were cultured on ma...
متن کاملIdentification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis.
OBJECTIVES During recent decades, the number of invasive fungal infections among immunosuppressed patients has increased significantly, whereas the number of effective systemic antifungal drugs remains low and unsatisfactory. The aim of this study was to characterize a novel antifungal compound, CW-8/haemofungin, which we previously identified in a screen for compounds affecting fungal cell wal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 43 6 شماره
صفحات -
تاریخ انتشار 1990